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N‐myc  belongs to the  myc  proto‐oncogene family, which is involved in numerous cellular processes such as proliferation, growth, apoptosis, and differentiation. Conditional deletion of  N‐myc  in the mouse nervous system disrupted brain development, indicating that  N‐myc  plays an essential role during neural development. How the development of the olfactory epithelium and neurogenesis within are affected by the loss of  N‐myc  has, however, not been determined. To address these issues, we examined an  N‐myc Foxg1Cre   conditional mouse line, in which  N‐myc  is depleted in the olfactory epithelium. First changes in  N‐myc  mutants were detected at E11.5, with reduced proliferation and neurogenesis in a slightly smaller olfactory epithelium. The phenotype was more pronounced at E13.5, with a complete lack of  Hes5 ‐positive progenitor cells, decreased proliferation, and neurogenesis. In addition, stereological analyses revealed reduced cell size of post‐mitotic neurons in the olfactory epithelium, which contributed to a smaller olfactory pit. Furthermore, we observed diminished proliferation and neurogenesis also in the vomeronasal organ, which likewise was reduced in size. In addition, the generation of gonadotropin‐releasing hormone neurons was severely reduced in  N‐myc  mutants. Thus, diminished neurogenesis and proliferation in combination with smaller neurons might explain the morphological defects in the  N‐myc  depleted olfactory structures. Moreover, our results suggest an important role for  N‐myc  in regulating ongoing neurogenesis, in part by maintaining the  Hes5 ‐positive progenitor pool. In summary, our results provide evidence that  N‐myc  deficiency in the olfactory epithelium progressively diminishes proliferation and neurogenesis with negative consequences at structural and cellular levels. © 2013 The Authors. Developmental Neurobiology Published by Wiley Periodicals, Inc. Develop Neurobiol 74: 643–656, 2014

Progressive effects of N‐myc deficiency on proliferation, neurogenesis, and morphogenesis in the olfactory epithelium