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Lixisenatide as add‐on treatment among patients with different β‐cell function levels as assessed by HOMA‐β index
Author(s) -
Bonadonna Riccardo C.,
Blonde Lawrence,
Antsiferov Mikhail,
Berria Rachele,
Gourdy Pierre,
Hatunic Mensud,
Mohan Viswanathan,
Horowitz Michael
Publication year - 2017
Publication title -
diabetes/metabolism research and reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.307
H-Index - 110
eISSN - 1520-7560
pISSN - 1520-7552
DOI - 10.1002/dmrr.2897
Subject(s) - lixisenatide , medicine , postprandial , glycated hemoglobin , endocrinology , type 2 diabetes mellitus , diabetes mellitus , type 2 diabetes , glycemic , cohort , post hoc analysis , gastroenterology , exenatide , insulin
Abstract Background The effect of lixisenatide—a prandial once‐daily glucagon‐like peptide‐1 receptor agonist—on glycaemic control in patients with inadequately controlled type 2 diabetes mellitus (T2DM), stratified by baseline β‐cell function, was assessed. Methods The 24‐week GetGoal‐M, ‐P and ‐S trials evaluated the efficacy and safety of lixisenatide in combination with oral antidiabetic agents. This post hoc analysis used data from patients receiving lixisenatide in these trials, divided into matched cohorts by propensity scoring, and stratified according to baseline homeostasis model assessment of β‐cell function (HOMA‐β) index levels, high HOMA‐β: > median HOMA‐β (28.49%); low HOMA‐β: ≤ median. Results The matched “low” and “high” HOMA‐β index cohorts (N = 546 patients) had comparable baseline parameters. Mean change from baseline in glycated haemoglobin (HbA 1c ) was −0.85% and −0.94% for low and high HOMA‐β cohorts, respectively ( P = .2607). Reductions from baseline in fasting plasma glucose (FPG; −0.77 vs −1.04 mmol/L; P = .1496) and postprandial plasma glucose (PPG; −5.82 vs −5.61 mmol/L; P = .7511) were similar in the low versus high HOMA‐β index cohorts. Reduction in body weight was significantly greater in the low versus high HOMA‐β index cohort (–2.06 vs –1.13 kg, respectively; P = .0006). Conclusions In patients with T2DM, lixisenatide was associated with reduction in HbA 1c and improvements in both FPG and PPG, regardless of β‐cell function, indicating that lixisenatide is effective in reducing hyperglycaemia, even in patients with more advanced stages of T2DM and poor residual β‐cell function.