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Carboxylated and undercarboxylated osteocalcin in metabolic complications of human obesity and prediabetes
Author(s) -
Razny Urszula,
Fedak Danuta,
KiecWilk Beata,
Goralska Joanna,
Gruca Anna,
Zdzienicka Anna,
KiecKlimczak Malgorzata,
Solnica Bogdan,
HubalewskaDydejczyk Alicja,
MalczewskaMalec Malgorzata
Publication year - 2017
Publication title -
diabetes/metabolism research and reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.307
H-Index - 110
eISSN - 1520-7560
pISSN - 1520-7552
DOI - 10.1002/dmrr.2862
Subject(s) - medicine , endocrinology , resistin , adiponectin , prediabetes , insulin resistance , osteocalcin , adipokine , obesity , leptin , body mass index , diabetes mellitus , chemistry , type 2 diabetes , alkaline phosphatase , biochemistry , enzyme
Background Carboxylated osteocalcin (Gla‐OC) participates in bone remodeling, whereas the undercarboxylated form (Glu‐OC) takes part in energy metabolism. This study was undertaken to compare the blood levels of Glu‐OC and Gla‐OC in nonobese, healthy obese, and prediabetic volunteers and correlate it with the metabolic markers of insulin resistance and early markers of inflammation. Methods Nonobese (body mass index [BMI] <30 kg/m 2 ; n = 34) and obese subjects (30