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Sub‐library composition of peptide libraries: Potential application in screening
Author(s) -
Furka ÁrpáD
Publication year - 1994
Publication title -
drug development research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.582
H-Index - 60
eISSN - 1098-2299
pISSN - 0272-4391
DOI - 10.1002/ddr.430330205
Subject(s) - peptide , peptide library , chemistry , combinatorial chemistry , order (exchange) , computer science , computational biology , biology , biochemistry , peptide sequence , business , finance , gene
Abstract Peptide sub‐libraries and omission sub‐libraries derived from parent peptide libraries synthesized with the portioning‐mixing method are defined. They can be distinguished by their order, i.e., the number of non‐varied positions or omission positions in the molecules. The number of types of sub‐libraries as well as the number of their components depend on both the order and the number of residues. Sub‐libraries belonging to a given residue number and a given order altogether form a kit. The paper outlines the potential use of sub‐libraries and other kinds of partial libraries in identification of the bioactive components of peptide and other kinds of biooligomer libraries. © 1994 Wiley‐Less, Inc.