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Mercury‐Free Synthesis of Pincer [C^N^C]Au III Complexes by an Oxidative Addition/CH Activation Cascade
Author(s) -
Eppel Daniel,
Rudolph Matthias,
Rominger Frank,
Hashmi A. Stephen K.
Publication year - 2020
Publication title -
chemsuschem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.412
H-Index - 157
eISSN - 1864-564X
pISSN - 1864-5631
DOI - 10.1002/cssc.202000310
Subject(s) - mercury (programming language) , chemistry , dimethyl sulfide , pincer movement , sulfide , combinatorial chemistry , photosensitizer , selectivity , luminescence , chloride , photochemistry , cascade , catalysis , organic chemistry , sulfur , materials science , optoelectronics , chromatography , computer science , programming language
Starting from the commercially available dimethyl sulfide‐gold(I) chloride complex (DMSAuCl) and diazonium salts in the presence of 2,6‐di‐ tert ‐butyl‐4‐methylpyridine as base, symmetric and unsymmetric [C^N^C]Au III Cl complexes were synthesized in a selective, photosensitizer‐free, photochemical reaction using blue LED light. This new protocol provides the first mercury‐free synthesis of these types of pincer‐complexes in moderate‐to‐excellent yields, starting from a readily available gold(I) precursor. Owing to the extraordinary properties of the target compounds, like excellent luminescence and high anticancer activities, the synthesis of such complexes is a highly active field of research, which might make its way to an industrial application. Owing to the disadvantages of the known protocols, especially the toxicity and the selectivity issues in the case of unsymmetric complexes, avoiding the use of mercury, should further accelerate this ongoing development.