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Comparison of guanadrel and guanethidine
Author(s) -
Hansson Lennart,
Pascual Arturo,
Julius Stevo
Publication year - 1973
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1973142204
Subject(s) - medicine , guanethidine , potency , blood pressure , morning , placebo , anesthesia , vascular resistance , cardiology , chemistry , biochemistry , alternative medicine , pathology , stimulation , in vitro
Both guanadrel and guanethidine caused a statistically significant reduction of blood pressure when compared to placebo, but there was no significant difference between the 2 drugs, regarding antihypertensive potency. With guanadrel it was possible to achieve significantly more control of the blood pressure throughout the day. There also were fewer complaints of early morning dizziness during the guanadrel period, and there was less diarrhea. The effects of both drugs on cardiac output and total peripheral vascular resistance were identical in the resting recumbent position and during tilting.