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Lysosomal solute carrier transporters gain momentum in research
Author(s) -
Bissa B,
Beedle AM,
Govindarajan R
Publication year - 2016
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt.450
Subject(s) - lysosome , transporter , autophagy , exocytosis , microbiology and biotechnology , solute carrier family , adenosine triphosphate , lysosomal storage disease , cytoplasm , biology , function (biology) , membrane transport protein , biochemistry , chemistry , enzyme , secretion , apoptosis , gene
Emerging evidence indicates that lysosome function extends beyond macromolecular degradation. Genetic and functional defects in components of the lysosomal transport machinery cause lysosomal storage disorders implicating the lysosomal solute carrier (SLC) transporters as essential to vital cell processes. The pathophysiology and therapeutic potential of lysosomal SLC transporters are highlighted here, focusing on recent discoveries in autophagic amino acid sensing (SLC38A9), phagocytic regulation in macrophages (SLC29A3, SLC15A3/A4), adenosine triphosphate (ATP) exocytosis in neurotransmission (SLC17A9), and lysosomal transport of maytansine catabolites into the cytoplasm (SLC46A3).