Premium
Trial design innovations: Clinical trials for treatment of neuropsychiatric symptoms in Alzheimer's Disease
Author(s) -
Cummings J,
Zhong K
Publication year - 2015
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt.190
Subject(s) - apathy , clinical trial , disease , psychosis , medicine , quality of life (healthcare) , alzheimer's disease , psychiatry , dementia , cognitive impairment , cognition , nursing
Neuropsychiatric symptoms are common in Alzheimer's disease (AD) and other neurodegenerative disorders. Recent progress has been made with clinical trials, advancing new therapies for psychosis in Parkinson's disease (PD), agitation in AD, and apathy in AD. Definitions have emerged for agitation and apathy in patients with cognitive impairment, facilitating recruitment of clinical trial populations. Progress in clinical trial design and the agents being assessed promise to advance therapies for disabling symptoms and improve quality of life for patients and caregivers.