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Comparison of Different Strategies to Measure Medication Adherence via Claims Data in Patients With Chronic Heart Failure
Author(s) -
Ihle Peter,
Krueger Katrin,
Schubert Ingrid,
GrieseMammen Nina,
Parrau Natalie,
Laufs Ulrich,
Schulz Martin
Publication year - 2019
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt.1378
Subject(s) - percentile , medicine , heart failure , retrospective cohort study , cohort , chronic disease , emergency medicine , intensive care medicine , cardiology , statistics , mathematics
Medication adherence correlates with morbidity and mortality in patients with chronic heart failure ( CHF ), but is difficult to assess. We conducted a retrospective methodological cohort study in 3,808 CHF patients, calculating adherence as proportion of days covered ( PDC ) utilizing claims data from 2010 to 2015. We aimed to compare different parameters’ influence on the PDC of elderly CHF patients exemplifying a complex chronic disease. Investigated parameters were the assumed prescribed daily dose ( PDD ), stockpiling, and periods of hospital stay. Thereby, we investigated a new approach using the PDD assigned to different percentiles. The different dose assumptions had the biggest influence on the PDC , with variations from 41.9% to 83.7%. Stockpiling and hospital stays increased the values slightly. These results queries that a reliable PDC can be calculated with an assumed PDD . Hence, results based on an assumed PDD have to be interpreted carefully and should be presented with sensitivity analyses to show the PDC 's possible range.