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Pharmacogene Variation Consortium Gene Introduction: NUDT15
Author(s) -
Yang Jun J.,
WhirlCarrillo Michelle,
Scott Stuart A.,
Turner Amy J.,
Schwab Matthias,
Tanaka Yoichi,
SuarezKurtz Guilherme,
Schaeffeler Elke,
Klein Teri E.,
Miller Neil A.,
Gaedigk Andrea
Publication year - 2019
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt.1268
Subject(s) - thiopurine methyltransferase , pharmacogenetics , biology , single nucleotide polymorphism , allele , genetics , pharmacology , genotype , gene , medicine , inflammatory bowel disease , disease
The Pharmacogene Variation (PharmVar) Consortium is the successor of the Human Cytochrome P450 (CYP) Allele Nomenclature website that served the pharmacogenetics community by designating CYP star (*) alleles. The aim of PharmVar is to continue the mission of serving as an official allele designation authority for the global pharmacogenetics community. Herein, we describe the introduction of the first nonCYP gene to PharmVar. Pharmacogenetic variation of NUDT15 plays a significant role in thiopurine response variability and toxicity.

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