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Patient Enrichment for Precision‐Based Cancer Clinical Trials: Using Prospective Cohort Surveillance as an Approach to Improve Clinical Trials
Author(s) -
Dalton William S.,
Sullivan Daniel,
Ecsedy Jeffrey,
Caligiuri Michael A.
Publication year - 2018
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt.1051
Subject(s) - clinical trial , medicine , prospective cohort study , cohort , cancer , identification (biology) , precision medicine , intensive care medicine , oncology , pathology , botany , biology
Technological advances have led to the identification of biomarkers and development of novel target‐based therapies. While some novel therapies have improved patient outcomes, the prevalence and diversity of biomarkers and targets in patient populations, especially patients with cancer, has created a challenge for the design and performance of clinical trials. To address this challenge we propose that prospective cohort surveillance of patients may be a solution to promote clinical trial matching for patients in need.

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