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The Afirma Xpression Atlas for thyroid nodules and thyroid cancer metastases: Insights to inform clinical decision‐making from a fine‐needle aspiration sample
Author(s) -
Krane Jeffrey F.,
Cibas Edmund S.,
Endo Mayumi,
Marqusee Ellen,
Hu Mimi I.,
Nasr Christian E.,
Waguespack Steven G.,
Wirth Lori J.,
Kloos Richard T.
Publication year - 2020
Publication title -
cancer cytopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.29
H-Index - 57
eISSN - 1934-6638
pISSN - 1934-662X
DOI - 10.1002/cncy.22300
Subject(s) - medicine , thyroid nodules , thyroid , thyroid cancer , prognostics , clinical decision making , classifier (uml) , clinical practice , oncology , intensive care medicine , bioinformatics , medical physics , pathology , radiology , physical therapy , artificial intelligence , data mining , biology , computer science
Recent analytical and clinical validation of the Afirma Xpression Atlas (XA) demonstrates test reliability and the identification of genomic alterations that may inform patient management. The updated Afirma Genomic Sequencing Classifier and XA reports aim to optimize the understanding of these contributions, including decisions about observation versus surgery, the need for disease‐specific preoperative testing, associated neoplasm types, prognostics, the identification of molecular targets for systemic therapy, and the recognition of potential hereditary syndromes.