Open AccessQuantitation of a spin polarization‐induced nuclear Overhauser effect (SPINOE) between a hyperpolarized 13 C‐labeled cell metabolite and water protons
Author(s) -
MarcoRius Irene,
Bohndiek Sarah E.,
Kettunen Mikko I.,
Larkin Timothy J.,
Basharat Meer,
Seeley Colm,
Brindle Kevin M.
Publication year - 2014
Publication title -
contrast media & molecular imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.714
H-Index - 50
eISSN - 1555-4317
pISSN - 1555-4309
DOI - 10.1002/cmmi.1556
Subject(s) - nuclear overhauser effect , hyperpolarization (physics) , chemistry , spins , polarization (electrochemistry) , nuclear magnetic resonance , spin diffusion , analytical chemistry (journal) , nuclear magnetic resonance spectroscopy , physics , diffusion , condensed matter physics , chromatography , thermodynamics
The spin polarization‐induced nuclear Overhauser effect (SPINOE) describes the enhancement of spin polarization of solvent nuclei by the hyperpolarized spins of a solute. In this communication we demonstrate that SPINOEs can be observed between [1,4‐ 13 C 2 ]fumarate, hyperpolarized using the dissolution dynamic nuclear polarization technique, and solvent water protons. We derive a theoretical expression for the expected enhancement and demonstrate that this fits well with experimental measurements. Although the magnitude of the effect is relatively small (around 2% measured here), the SPINOE increases at lower field strengths, so that at clinically relevant magnetic fields (1.5–3 T) it may be possible to track the passage through the circulation of a bolus containing a hyperpolarized 13 C‐labeled substrate through the increase in solvent water 1 H signal. © 2014 The Authors. Contrast Media & Molecular Imaging published by John Wiley and Sons, Ltd.