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The spin polarization‐induced nuclear Overhauser effect (SPINOE) describes the enhancement of spin polarization of solvent nuclei by the hyperpolarized spins of a solute. In this communication we demonstrate that SPINOEs can be observed between [1,4‐ 13 C 2 ]fumarate, hyperpolarized using the dissolution dynamic nuclear polarization technique, and solvent water protons. We derive a theoretical expression for the expected enhancement and demonstrate that this fits well with experimental measurements. Although the magnitude of the effect is relatively small (around 2% measured here), the SPINOE increases at lower field strengths, so that at clinically relevant magnetic fields (1.5–3 T) it may be possible to track the passage through the circulation of a bolus containing a hyperpolarized  13 C‐labeled substrate through the increase in solvent water  1 H signal. © 2014 The Authors.  Contrast Media &amp; Molecular Imaging  published by John Wiley and Sons, Ltd.

contrast media & molecular imaging

Quantitation of a spin polarization‐induced nuclear Overhauser effect (SPINOE) between a hyperpolarized  13 C‐labeled cell metabolite and water protons