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Synthesis and Antimicrobial Evaluation of Bis‐morpholine Triazine Quaternary Ammonium Salts
Author(s) -
Morandini Andrea,
Leonetti Benedetta,
Riello Pietro,
Sole Roberto,
Gatto Vanessa,
Caligiuri Isabella,
Rizzolio Flavio,
Beghetto Valentina
Publication year - 2021
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.202100409
Subject(s) - antimicrobial , morpholine , chemistry , ammonium , escherichia coli , triazine , staphylococcus aureus , bacteria , antibacterial activity , cytotoxicity , combinatorial chemistry , microbiology and biotechnology , organic chemistry , biochemistry , biology , in vitro , genetics , gene
Efficient, environmentally and economically sustainable, and nontoxic antibacterial products are of global relevance in the fight against microorganism contamination. In this work, an easy and straightforward method for the synthesis of bis‐morpholino triazine quaternary ammonium salts (bis‐mTQAS) is reported, starting from 2,4,6‐trichloro‐1,3,5‐triazine or 2,4‐dichloro‐6‐methoxy‐1,3,5‐triazine and various N ‐alkylmorpholines. Bis‐mTQAS were tested as antimicrobials against Gram‐negative and Gram‐positive bacterial strains. The best‐performing bis‐mTQAS were found to achieve total disinfection against Staphylococcus aureus ATCC 25923 and Escherichia coli ATCC 25922 at 50 and 400 μg/mL, respectively. Distinctively, bis‐mTQAS with the highest antimicrobial efficiency had lowest cytotoxicity.