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Functionalized Cyclopentenones and an Oxime Ether as Antimicrobial Agents
Author(s) -
Gomes Rafael F. A.,
Isca Vera M. S.,
Andrade Késsia,
Rijo Patrícia,
Afonso Carlos A. M.
Publication year - 2021
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.202100369
Subject(s) - antimicrobial , furfural , chemistry , ether , oxime , bacteria , organic chemistry , combinatorial chemistry , biology , catalysis , genetics
Several naturally occurring cyclopentenones, such as palmenones and nigrosporiones, exhibit antimicrobial activity. Herein we describe the antimicrobial activity of cyclopentenones and derivatives that can be easily accessed from biomass derivatives furfural and 5‐hydroxymethylfurfural. Upon screening a range of functionalized trans‐ diamino‐cyclopentenones (DCPs) and δ‐lactone‐fused cyclopentenones (LCPs), an oxime ether derivative of DCP was identified that exhibited remarkable antimicrobial activity against Gram‐positive bacteria, including resistant strains such as methicillin‐resistant S. aureus (MRSA) and vancomycin‐resistant E. faecalis (VRE) strains.