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Radiolabelled Cyclic Bisarylmercury: High Chemical and in vivo Stability for Theranostics
Author(s) -
Gilpin Ian Moore F.,
Ullrich Martin,
Wünsche Thomas,
Zarschler Kristof,
Lebeda Ondřej,
Pietzsch Jens,
Pietzsch HansJürgen,
Walther Martin
Publication year - 2021
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.202100131
Subject(s) - chemistry , in vivo , biodistribution , mercury (programming language) , chemical stability , dissociation (chemistry) , combinatorial chemistry , stereochemistry , radiochemistry , in vitro , organic chemistry , biochemistry , microbiology and biotechnology , computer science , biology , programming language
We show the synthesis of an in vivo stable mercury compound with functionality suitable for radiopharmaceuticals. The designed cyclic bisarylmercury was based on the water tolerance of organomercurials, higher bond dissociation energy of Hg−Ph to Hg−S, and the experimental evidence that acyclic structures suffer significant cleavage of one of the Hg−R bonds. The bispidine motif was chosen for its in vivo stability, chemical accessibility, and functionalization properties. Radionuclide production results in 197(m) HgCl 2 (aq), so the desired mercury compound was formed via a water‐tolerant organotin transmetallation. The Hg‐bispidine compound showed high chemical stability in tests with an excess of sulfur‐containing competitors and high in vivo stability, without any observable protein interaction by human serum assay, and good organ clearance demonstrated by biodistribution and SPECT studies in rats. In particular, no retention in the kidneys was observed, typical of unstable mercury compounds. The nat Hg analogue allowed full characterization by NMR and HRMS.