Open AccessKRAS mutation in papillary fibroelastoma: a true cardiac neoplasm?
Author(s) -
Wittersheim Maike,
Heydt Carina,
Hoffmann Fabian,
Büttner Reinhard
Publication year - 2017
Publication title -
the journal of pathology: clinical research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.849
H-Index - 21
ISSN - 2056-4538
DOI - 10.1002/cjp2.66
Subject(s) - kras , etiology , papillary fibroelastoma , mutation , medicine , pathology , neoplasm , heart neoplasms , cardiac tumors , cancer research , cancer , biology , gene , genetics , colorectal cancer
Primary cardiac tumours are rare and mostly benign lesions. Recent publications report that cardiac papillary fibroelastomas are the most common benign primary heart tumour, outnumbering myxomas. However, there is no consensus about their aetiology. We investigated the molecular profile of these tumours using next generation sequencing in a cohort of 16 cases. Eleven of 14 (79%) analysable tumours showed mutations of the KRAS oncogene. Our results provide unambiguous evidence that a significant proportion of these lesions are genuine neoplastic tumours caused by an oncogenic driver mutation.