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Precise parameter estimation in reaction modelling — sensitivity in choosing experimental conditions
Author(s) -
Mezaki Reiji
Publication year - 1969
Publication title -
the canadian journal of chemical engineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.404
H-Index - 67
eISSN - 1939-019X
pISSN - 0008-4034
DOI - 10.1002/cjce.5450470217
Subject(s) - sensitivity (control systems) , experimental data , estimation theory , model parameter , mathematics , design of experiments , statistics , biological system , computer science , engineering , electronic engineering , biology
A sequential experimental design developed by Box and coworkers was reviewed and the sensitivity of experimental conditions in increasing the preciseness of parameter estimates was examined. Continuous kinetic data were utilized for the examination. It is found that experimental conditions are in some cases rather sinsitive and slightly deviated experimental conditions from those specified by the criterion may induce some difficulty in reducing the size of confidence region of parameter estimates.