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2 ‐O‐ Acetyl‐3,4,5,6‐tetra ‐O‐ benzyl‐ d ‐ myo ‐inosityl diphenylphosphate: A new useful intermediate to inositol phosphate and phospholipids
Author(s) -
Sangiorgio Sara,
Cambò Mattia,
Semproli Riccardo,
Ubiali Daniela,
Speranza Giovanna,
Rabuffetti Marco
Publication year - 2022
Publication title -
chirality
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.43
H-Index - 77
eISSN - 1520-636X
pISSN - 0899-0042
DOI - 10.1002/chir.23457
Subject(s) - chemistry , tetra , inositol , phosphate , stereochemistry , medicinal chemistry , organic chemistry , biochemistry , receptor
Inositol phosphates and inositol phospholipids are ubiquitous in biochemistry and play a central role in cell signaling and regulation events. For this reason, their synthesis has attracted widespread interest. This paper describes the preparation of a new optically active inositol phosphate derivative, 2 ‐O‐ acetyl‐3,4,5,6‐tetra ‐O‐ benzyl‐ d ‐ myo ‐inosityl diphenylphosphate ( 6 ), and its characterization by spectroscopic methods. Compound ( 6 ) represents a useful intermediate for the preparation of inositol phosphate and phospholipids, in particular of glycerophosphoinositol (GPI), a natural anti‐inflammatory agent.