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Rigid and Compact Binuclear Bis‐hydrated Gd‐complexes as High Relaxivity MRI Agents
Author(s) -
Leone Loredana,
Guarnieri Luca,
Martinelli Jonathan,
Sisti Massimo,
Pei Andrea,
Botta Mauro,
Tei Lorenzo
Publication year - 2021
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.202101701
Subject(s) - pyridine , chemistry , crystallography , gadolinium , ligand (biochemistry) , molar ratio , medicinal chemistry , receptor , organic chemistry , biochemistry , catalysis
The first binuclear Gd‐complex of the 12‐membered pyridine‐based polyaminocarboxylate macrocyclic ligand PCTA was synthesized by C−C connection of the pyridine units through two different synthetic procedures. A dimeric AAZTA‐ligand was also synthesized with the aim to compare the relaxometric results or the two ditopic Gd‐complexes. Thus, the 1 H relaxometric study on [Gd 2 PCTA 2 (H 2 O) 4 ] and on [Gd 2 AAZTA 2 (H 2 O) 4 ] 2− highlighted the remarkable rigidity and compactness of the two binuclear complexes, which results in molar relaxivities (per Gd), at 1.5 T and 298 K of ca. 12–12.6 mM −1 s −1 with an increase of ca. 80 % at 1.5 T and 298 K (+70 % at 310 K) with respect to the corresponding mononuclear complexes.