English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Zendy Open

Presents the pdf analysis as premium feature

PDF Analysis

Insights

Presents the summarisation as premium feature

Summarisation

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the zaia usage as premium feature

ZAIA

Zendy Tools

Zendy Plus

Presents the access of premium content as premium feature

Premium Content

A gold‐catalyzed cycloisomerization of 2‐indolyl‐3‐[(trimethylsilyl)ethynyl)]quinoxalines with concomitant 1,2‐silyl shift forms 6‐(trimethylsilyl)indolo[3,2‐ a ]phenazines in moderate to excellent yield. These silylated heterocycles are readily transformed into 6‐aryl‐indolo[3,2‐ a ]phenazines in moderate to good yield by one‐pot  ipso ‐iodination Suzuki coupling. The title compounds represent a novel type of tunable luminophore. Structure‐property relationships for 6‐aryl‐indolo[3,2‐ a ]phenazines obtained from Hammett correlations with  σ   p+   substituent parameters indicate that emission maxima, Stokes shifts, and fluorescence quantum yields can be fine‐tuned by the remote  para ‐aryl substituent. Furthermore, indolo[3,2‐ a ]phenazines were found to exhibit interesting activities against medically relevant pathogens such as the Apicomplexa parasite  Toxoplasma gondii  with an IC 50  of up to 0.67±0.13 μM. Thus, these compounds are promising candidates for novel anti‐parasitic therapies.

chemistry – a european journal

Fluorescent Indolo[3,2‐ a ]phenazines against  Toxoplasma gondii : Concise Synthesis by Gold‐Catalyzed Cycloisomerization with 1,2‐Silyl Migration and  ipso ‐Iodination Suzuki Sequence