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Intermolecular Hydroaminoalkylation of Alkynes
Author(s) -
Kaper Tobias,
Fischer Malte,
Thye Hermann,
Geik Dennis,
Schmidtmann Marc,
Beckhaus Ruediger,
Doye Sven
Publication year - 2021
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.202100238
Subject(s) - intermolecular force , alkyne , alkene , allylic rearrangement , catalysis , chemistry , titanium , medicinal chemistry , polymer chemistry , organic chemistry , molecule
Intermolecular hydroaminoalkylation reactions of alkynes with secondary amines, which selectively give access to allylic amines with E configuration of the alkene unit, are achieved in the presence of titanium catalysts. Successful reactions of symmetrically substituted diaryl‐ and dialkylalkynes as well as a terminal alkyne take place with N ‐benzylanilines, N ‐alkylanilines, and N ‐alkylbenzylamines.