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Formulation of Next‐Generation Multicompartment Microcapsules by Reversible Electrostatic Attraction
Author(s) -
Neumann Christian,
Bacher Lisa,
Musyanovych Anna,
Tutus Murat,
Latnikova Alexandra
Publication year - 2021
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.202100183
Subject(s) - nanocapsules , surface charge , capsule , materials science , chemical engineering , coating , plga , electrostatic interaction , copolymer , nanotechnology , zeta potential , polymer chemistry , chemistry , polymer , nanoparticle , composite material , botany , chemical physics , engineering , biology
The combination of several active substances into one carrier is often limited due to solubility, stability and phase‐separation issues. These issues have been addressed by an innovative capsule design, in which nanocapsules are assembled on the microcapsule surface by electrostatic forces to form a pH‐responsive hierarchical capsule@capsule system. Here, melamine‐formaldehyde (MF) microcapsules with a negative surface charge were synthesized and coated with a novel MF‐polyethyleneimine (PEI) copolymer to achieve a positive charge of ζ =+28 mV. This novel coating procedure allows the electrostatic assembly of negatively charged poly‐ l ‐lactide (PLLA, ζ =−19 mV) and poly‐(lactide‐co‐glycolide) (PLGA, ζ =−56 mV) nanocapsules on the microcapsule surface. Assembly studies at pH 7 gave a partial surface coverage of PLLA nanocapsules and full surface coverage for PLGA nanocapsules. The pH‐responsive adsorption and desorption of nanocapsules was shown at pH 7 and pH 3.