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A Switchable Catalyst Duo for Acyl Transfer Proximity Catalysis and Regulation of Substrate Selectivity
Author(s) -
Goswami Abir,
Gaikwad Sudhakar,
Schmittel Michael
Publication year - 2021
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.202004416
Subject(s) - catalysis , selectivity , substrate (aquarium) , chemistry , allosteric regulation , reactivity (psychology) , combinatorial chemistry , enzyme , organic chemistry , biology , medicine , alternative medicine , pathology , ecology
Enzymes are encoded with a gamut of information to catalyze a highly selective transformation by selecting the proper reactants from an intricate mixture of constituents. Mimicking biological machinery, two switchable catalysts with differently sized cavities and allosteric control are conceived that allow complementary size‐selective acyl transfer in an on/off manner by modulating the effective local concentration of the substrates. Selective activation of one of two catalysts in a mixture of reactants of similar reactivity enabled upregulation of the desired product.