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Insights into Ruthenium(II/IV)‐Catalyzed Distal C−H Oxygenation by Weak Coordination
Author(s) -
Bu Qingqing,
Kuniyil Rositha,
Shen Zhigao,
Gońka Elżbieta,
Ackermann Lutz
Publication year - 2020
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.202003062
Subject(s) - ruthenium , catalysis , aryl , chemistry , hydroxylation , medicinal chemistry , alkyl , reductive elimination , combinatorial chemistry , organic chemistry , enzyme
C−H hydroxylation of aryl acetamides and alkyl phenylacetyl esters was accomplished via challenging distal weak O‐ coordination by versatile ruthenium(II/IV) catalysis. The ruthenium(II)‐catalyzed C−H oxygenation of aryl acetamides proceeded through C−H activation, ruthenium(II/IV) oxidation and reductive elimination, thus providing step‐economical access to valuable phenols. The p ‐cymene‐ruthenium(II/IV) manifold was established by detailed experimental and DFT‐computational studies.