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Recent Advances of the Halogen–Zinc Exchange Reaction
Author(s) -
Balkenhohl Moritz,
Knochel Paul
Publication year - 2020
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201904794
Subject(s) - halogen , zinc , reagent , chemistry , lithium (medication) , nitro , combinatorial chemistry , organic chemistry , inorganic chemistry , medicine , alkyl , endocrinology
For the preparation of zinc organometallics bearing highly sensitive functional groups such as ketones, aldehydes or nitro groups, especially mild halogen–zinc exchange reagents have proven to be of great potential. In this Minireview, the latest research in the area of the halogen–zinc exchange reaction is reported, with a special focus lying on novel dialkylzinc reagents complexed with lithium alkoxides. Additionally, the preparation and application of organofluorine zinc reagents and transition‐metal‐catalyzed halogen–zinc exchange reactions are reviewed.