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Site‐Selective, Remote sp 3 C−H Carboxylation Enabled by the Merger of Photoredox and Nickel Catalysis
Author(s) -
Sahoo Basudev,
Bellotti Peter,
JuliáHernández Francisco,
Meng QingYuan,
Crespi Stefano,
König Burkhard,
Martin Ruben
Publication year - 2019
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201902095
Subject(s) - carboxylation , catalysis , alkyl , halide , nickel , selectivity , reactivity (psychology) , ligand (biochemistry) , chemistry , photochemistry , combinatorial chemistry , organic chemistry , medicine , biochemistry , alternative medicine , receptor , pathology
A photoinduced carboxylation of alkyl halides with CO 2 at remote sp 3 C−H sites enabled by the merger of photoredox and Ni catalysis is described. This protocol features a predictable reactivity and site selectivity that can be modulated by the ligand backbone. Preliminary studies reinforce a rationale based on a dynamic displacement of the catalyst throughout the alkyl side chain.