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Saccharide‐Containing Dynamic Proteoids
Author(s) -
Liu Yun,
Stuart Marc C. A.,
Witte Martin D.,
Buhler Eric,
Hirsch Anna K. H.
Publication year - 2017
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201703584
Subject(s) - biocompatibility , dynamic covalent chemistry , dipeptide , sugar , chemistry , covalent bond , amino acid , organic chemistry , combinatorial chemistry , biochemistry , molecule , supramolecular chemistry
Abstract Dynamic proteoids are dynamic covalent analogues of proteins, which can be used as new adaptive biomaterials. We designed and synthesized a range of sugar‐containing dynamic proteoid biodynamers based on the polycondensation of different types of amino acid and dipeptide hydrazides with a biological aliphatic dialdehyde and a nonbiological aromatic dialdehyde. By using the saccharide‐based dialdehyde, the biocompatibility of biodynamers should be enhanced compared to previously reported biodynamers.