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Hybridizing Simulated Moving Bed and Electrodialysis: Product Purification and Eluent Regeneration
Author(s) -
Kochendoerfer Kiara,
Sa Gomes Pedro,
Rütze Dennis N.,
Pathapati Trinath,
Wit Pieter,
Zaalberg Menne
Publication year - 2018
Publication title -
chemical engineering and technology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.403
H-Index - 81
eISSN - 1521-4125
pISSN - 0930-7516
DOI - 10.1002/ceat.201800298
Subject(s) - electrodialysis , column chromatography , simulated moving bed , chromatography , chemistry , packed bed , process (computing) , process engineering , computer science , membrane , engineering , adsorption , organic chemistry , biochemistry , operating system
Complex streams in bio‐based industries require efficient downstream processing units. Simulated moving‐bed (SMB) chromatography is known to improve process efficiency by reducing resin and buffer requirement, but it can be further enhanced by technology hybridization. In the current experiments, an SMB system has been integrated with a bipolar electrodialysis (BPED) system. SMB purified γ ‐aminobutyric acid (GABA) from a clarified fermentation broth while BPED processed the product‐containing eluent stream into recyclable eluent and purified product streams. The continuous operation did not result in any impurity accumulation.