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Efficient and Practical Transfer Hydrogenation of Ketones Catalyzed by a Simple Bidentate Mn−NHC Complex
Author(s) -
Putten Robbert,
Benschop Joeri,
Munck Vincent J.,
Weber Manuela,
Müller Christian,
Filonenko Georgy A.,
Pidko Evgeny A.
Publication year - 2019
Publication title -
chemcatchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.497
H-Index - 106
eISSN - 1867-3899
pISSN - 1867-3880
DOI - 10.1002/cctc.201900882
Subject(s) - catalysis , transfer hydrogenation , denticity , chemistry , metal , manganese , combinatorial chemistry , organic chemistry , ruthenium
Catalytic reductions of carbonyl‐containing compounds are highly important for the safe, sustainable, and economical production of alcohols. Herein, we report on the efficient transfer hydrogenation of ketones catalyzed by a highly potent Mn(I)−NHC complex. Mn−NHC 1 is practical at metal concentrations as low as 75 ppm, thus approaching loadings more conventionally reserved for noble metal based systems. With these low Mn concentrations, catalyst deactivation is found to be highly temperature dependent and becomes especially prominent at increased reaction temperature. Ultimately, understanding of deactivation pathways could help close the activity/stability‐gap with Ru and Ir catalysts towards the practical implementation of sustainable earth‐abundant Mn‐complexes.