Open AccessZoledronic acid for neonatal subcutaneous fat necrosis
Author(s) -
Di Bari Jeremy A.,
Nead Jennifer A.,
Schurman Scott J.
Publication year - 2017
Publication title -
clinical case reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.21
H-Index - 9
ISSN - 2050-0904
DOI - 10.1002/ccr3.855
Subject(s) - zoledronic acid , medicine , bone resorption , calcium , prednisolone , gastroenterology , endocrinology , urology
Key Clinical Message Subcutaneous fat necrosis ( SFN ) in infants producing severe hypercalcemia is a life‐threatening emergency. Pathophysiology may include enhanced gastrointestinal calcium absorption and bone resorption. We treated an infant with SFN and serum calcium of 15 mg/dL with prednisolone and low‐dose zoledronic acid. Serum calcium promptly normalized without rebound hypocalcemia, and redosing of zoledronic acid was not necessary.