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Key Clinical Message  We presented the first case of four‐factor prothrombin complex concentrate (4F‐ PCC ) for the alleviation of bleeding for emergent on‐pump coronary artery bypass graft (CABG) with the patient discharged by postoperative day (POD) 9 with no sequelae. Until direct antidotes are available, 4F‐ PCC  may play a role in the management of mitigating rivaroxaban‐induced bleeding in surgical procedure.

Use of four‐factor prothrombin complex concentrate for the mitigation of rivaroxaban‐induced bleeding in an emergent coronary artery bypass graft