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Key Clinical Message  Fat embolism syndrome ( FES ) is a rare complication of sickle‐cell disease ( SCD ) associated with extremely high mortality rates. It affects predominantly non‐ SS  patients and those with previously mild disease. Rapid institution of exchange transfusion with an aim to reduce HbS to very low levels as soon as  FES  is suspected can be life‐saving.

Successful outcome of three patients with sickle‐cell disease and fat embolism syndrome treated with intensive exchange transfusion