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Key Clinical Message  In patients with atypical Crohn's disease features, including severe oral ulcerations and resistance to standard treatment, the possibility of a mature clonal CD8 +  T‐cell lymphoproliferative disorder should be investigated. Clinicians should be aware of this differential diagnosis because CD8 +  T‐cell lymphoma prognosis can be remarkably favorable upon oral treatment with cyclophosphamide.

Mature CD8 + T‐cell clonal expansion in the oral cavity and digestive tract: a severe lymphoid malignancy that mimics Crohn's disease