Open AccessThe potential role of HER 2 upregulation in metastatic breast cancer to the uterus: a case report
Author(s) -
Moey Melissa Y. Y.,
Hassan Omer A.,
Papageorgiou Christos N.,
Schnepp Stephanie L.,
Hoff John T.
Publication year - 2016
Publication title -
clinical case reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.21
H-Index - 9
ISSN - 2050-0904
DOI - 10.1002/ccr3.602
Subject(s) - medicine , metastatic breast cancer , downregulation and upregulation , uterus , breast cancer , metastasis , pathogenesis , endometrial cancer , cancer , hormone , oncology , cancer research , biology , biochemistry , gene
Key Clinical Message Abnormal uterine bleeding in a patient on maintenance hormonal therapy for breast cancer should raise concern for endometrial abnormalities including rare uterine metastasis from the breast. Hormonal receptor profile changes in metastatic lesions favoring human epidermal growth factor receptor 2 ( HER 2) overexpression may be involved in the pathogenesis of metastasis to the uterus.