Open AccessA transient increase and subsequent sharp decrease of chemo‐refractory liver‐metastasized uterine cervical small cell carcinoma to autologous formalin‐fixed tumor vaccine plus anti‐ PD ‐1 antibody
Author(s) -
Miyoshi Tatsu,
Kataoka Tatsuji,
Asahi Atsuko,
Maruyama Takashi,
Okada Rika,
Uemae Yoji,
Ohno Tadao
Publication year - 2016
Publication title -
clinical case reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.21
H-Index - 9
ISSN - 2050-0904
DOI - 10.1002/ccr3.596
Subject(s) - medicine , refractory (planetary science) , pembrolizumab , cervical carcinoma , carcinoma , immunotherapy , oncology , gastroenterology , cervical cancer , cancer , physics , astrobiology
Key Clinical Message Uterine cervical small cell carcinoma is rare and aggressive with no standardized therapy. A patient bearing the advanced chemo‐refractory carcinoma, treated with a tumor vaccine combined with 1 mg/kg of pembrolizumab, showed a transient increase and subsequent sharp decrease of the liver‐metastasized lesion to less than half its maximum diameter.