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Key Clinical Message   TAMOF  is a devastating microangiopathy that can occur in association with the new onset of T1 DM , and should be considered with the onset of thrombocytopenia, renal failure, and raised  LDH . Treatment with fresh frozen plasma should be considered as a first‐line option in such cases prior to plasma exchange.

Thrombocytopenia‐associated multiorgan failure occurring in an infant at the onset of type 1 diabetes successfully treated with fresh frozen plasma