Open AccessLocal recurrence of pheochromocytoma in multiple endocrine neoplasia type 2A: a diagnostic and therapeutic challenge
Author(s) -
Tramunt Blandine,
Buffet Alexandre,
Grunenwald Solange,
Vezzosi Delphine,
Bennet Antoine,
Huyghe Eric,
Zerdoud Slimane,
Caron Philippe
Publication year - 2016
Publication title -
clinical case reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.21
H-Index - 9
ISSN - 2050-0904
DOI - 10.1002/ccr3.498
Subject(s) - metanephrines , medicine , pheochromocytoma , multiple endocrine neoplasia , multiple endocrine neoplasia type 2 , endocrine system , urinary system , paraganglioma , urology , pathology , hormone , germline mutation , biochemistry , chemistry , mutation , gene
Key Clinical Message In a patient with multiple endocrine neoplasia type 2A ( MEN 2A), an inverted physiological ratio between urinary normetanephrines and metanephrines is an early marker of recurrence in epinephrine‐secreting pheochromocytoma, and 131I MIBG treatment appears to be a useful therapeutic option in order to avoid multiple invasive surgical procedures in pheochromocytomatosis.