Open AccessIsodicentric Philadelphia chromosome: an uncommon chromosomal abnormality in the chronic phase of chronic myeloid leukemia ( CML )
Author(s) -
Loo Eric,
Bansal Pranshu,
Cherukuri Durga,
Arana Yi Cecilia
Publication year - 2016
Publication title -
clinical case reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.21
H-Index - 9
ISSN - 2050-0904
DOI - 10.1002/ccr3.444
Subject(s) - myeloid leukemia , medicine , dasatinib , imatinib mesylate , chromosomal abnormality , philadelphia chromosome , chromosome abnormality , imatinib , chronic myelogenous leukemia , chromosome , abnormality , cancer research , leukemia , immunology , chromosomal translocation , karyotype , genetics , biology , gene , psychiatry
Key Clinical Message An isodicentric Philadelphia chromosome is an uncommon finding previously described as a secondary chromosomal abnormality in accelerated‐ or blast‐phase of chronic myeloid leukemia ( CML ) with resistance to imatinib mesylate or dasatinib. Here, we present a case with idic(Ph) chromosome identified at initial diagnosis in a patient with chronic‐phase CML .