Open AccessEculizumab as a bridge to immunosuppressive therapy in severe cold agglutinin disease of anti‐Pr specificity
Author(s) -
Shapiro Roman,
ChinYee Ian,
Lam Selay
Publication year - 2015
Publication title -
clinical case reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.21
H-Index - 9
ISSN - 2050-0904
DOI - 10.1002/ccr3.399
Subject(s) - eculizumab , cold agglutinin disease , medicine , rituximab , hemolysis , autoimmune hemolytic anemia , immunology , complement system , hemolytic anemia , antibody
Key Clinical Message Severe cold agglutinin disease with hemodynamic compromise requires rapid stabilization of the autoimmune hemolytic anemia as a bridge to the immunosuppressive effect of rituximab. Herein, we describe eculizumab treatment of severe complement‐mediated hemolysis in a patient whose hemodynamic status deteriorated in spite of supportive blood transfusions and therapeutic plasma exchange.