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Key Clinical Message  A patient with a marginal zone lymphoma received  RCHOP  and obtained  PR . He received  RDHAP , autograft, and obtained  CR . Three months later, he developed Kaposi's sarcoma with spontaneous regression. Two months later, he developed  DLBCL  treated with R‐ MIV  with  CR . Thereafter, he developed  AML  and died a few days later.

Quadri‐lineage disease involving nodal B‐cell marginal zone lymphoma, high‐grade B‐cell lymphoma, Kaposi's syndrome, and acute myeloid leukemia