Open AccessEffect of S‐1 on blood levels of phenobarbital and phenytoin: A case report
Author(s) -
Shiraiwa Ken,
Ono Hiroyuki,
Tanaka Ryota,
Fujinaga Atsuro,
Hiratsuka Takahiro,
Tatsuta Ryosuke,
Inomata Masafumi,
Itoh Hiroki
Publication year - 2021
Publication title -
clinical case reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.21
H-Index - 9
ISSN - 2050-0904
DOI - 10.1002/ccr3.3813
Subject(s) - phenytoin , phenobarbital , medicine , tegafur , drug , pharmacology , plasma concentration , drug interaction , anesthesia , cancer , epilepsy , psychiatry
Drug‐drug interaction of fluorinated pyrimidine anticancer agents with phenytoin is well known, but interaction with phenobarbital is limited. We describe a case showing increases in plasma phenobarbital as well as phenytoin concentrations during preoperative S‐1 (tegafur/gimeracil/oteracil) and radiation therapy for rectal cancer.