z-logo
open-access-imgOpen Access
A case of antisynthetase syndrome with chilblains‐like lesions and microangiopathy
Author(s) -
Abrassart Tom,
Roland Thomas,
Laurent France,
Rossi Camelia
Publication year - 2021
Publication title -
clinical case reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.21
H-Index - 9
ISSN - 2050-0904
DOI - 10.1002/ccr3.3790
Subject(s) - antisynthetase syndrome , medicine , interstitial lung disease , dermatology , thrombotic microangiopathy , myalgia , pathology , microangiopathy , autoantibody , anti nuclear antibody , lung , disease , immunology , antibody , endocrinology , diabetes mellitus
We present the case of a 50‐year‐old woman with febrile myalgia, chilblains‐like lesions, and cough. Antinuclear antibodies and anti‐PL‐12 antisynthetase autoantibodies were found in complementary examinations. Interstitial lung disease was found on chest computed tomography. Nailfold capillaroscopy showed microangiopathic lesions. Antisynthetase syndrome is a recently described entity in inflammatory myopathies, with specific clinical criteria. Interstitial lung disease is very common, especially in anti‐PL‐12 associated antisynthetase syndrome. Raynaud's phenomenon is another well‐defined criterion. However, microangiopathic damage is probably underestimated and the role of nailfold capillaroscopy in the diagnosis has not been established yet.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.
Having issues? You can contact us here