Open AccessSignificant elevation of free itraconazole concentration at onset of adverse effects: A case report
Author(s) -
Tanaka Ryota,
Suzuki Yosuke,
Matsumoto Hiroyuki,
Yamasue Mari,
Umeki Kenji,
Hashinaga Kazuhiko,
Tatsuta Ryosuke,
Hiramatsu Kazufumi,
Kamei Katsuhiko,
Kadota Junichi,
Itoh Hiroki
Publication year - 2021
Publication title -
clinical case reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.21
H-Index - 9
ISSN - 2050-0904
DOI - 10.1002/ccr3.3726
Subject(s) - itraconazole , medicine , adverse effect , pharmacology , dermatology , antifungal
Free itraconazole and hydroxyitraconazole concentrations were markedly elevated despite almost no changes in total concentrations when itraconazole was discontinued due to adverse effects. Elevated free itraconazole concentration may have a causal relationship with the development of adverse effects.