Open AccessDiagnosis of intrachromosomal amplification of chromosome 21 ( iAMP 21) by molecular cytogenetics in pediatric acute lymphoblastic leukemia
Author(s) -
Duployez Nicolas,
BoudryLabis Elise,
Decool Gauthier,
Grzych Guillaume,
Grardel Nathalie,
Abou Chahla Wadih,
Preudhomme Claude,
RocheLestienne Catherine
Publication year - 2015
Publication title -
clinical case reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.21
H-Index - 9
ISSN - 2050-0904
DOI - 10.1002/ccr3.357
Subject(s) - lymphoblastic leukemia , cytogenetics , medicine , karyotype , single nucleotide polymorphism , chromosome , snp , snp array , leukemia , genetics , oncology , microbiology and biotechnology , biology , gene , genotype
Key Clinical Message Intrachromosomal amplification of chromosome 21 ( iAMP 21) defines a distinct cytogenetic subgroup of B‐cell precursor acute lymphoblastic leukemia ( BCP ‐ ALL ) with poor prognosis that should be investigated in routine practice. Single‐nucleotide polymorphism ( SNP )‐array provides a useful method to detect such cases showing a highly characteristic profile.