Open AccessEarly‐onset hypoparathyroidism and chronic keratitis revealing APECED
Author(s) -
Mezgueldi Ellia,
BertholetThomas Aurélia,
Milazzo Solange,
Morris Michael,
Bacchetta Justine,
Fabien Nicole,
Cochat Pierre,
Weetman Anthony P.,
Kemp Elizabeth Helen,
Belot Alexandre
Publication year - 2015
Publication title -
clinical case reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.21
H-Index - 9
ISSN - 2050-0904
DOI - 10.1002/ccr3.354
Subject(s) - chronic mucocutaneous candidiasis , hypoparathyroidism , medicine , dermatology , disease , immunology
Key Clinical Message Early diagnosis of potentially life‐threatening autoimmune polyendocrinopathy‐candidiasis‐ectodermal dystrophy ( APECED ) is crucial, but is often delayed due to the clinical heterogeneity of the disorder. Even in the absence of the classic disease triad of chronic mucocutaneous candidiasis, hypoparathyroidism, and adrenocortical insufficiency, a diagnosis of APECED should be considered in children who have hypoparathyroidism and chronic keratitis, with a past medical history showing a mild and transient C andida infection.