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Key Clinical Message  “Flare‐up” reactions are late manifestations of severe T‐cell‐mediated drug hypersensitivity reactions. Management is anti‐inflammatory treatment and avoiding unnecessary medicines. Symptoms like fever, lymph node swelling, and blood count abnormalities may lead to confusion with bacterial infections. For prompt recognition it is important to keep the differential diagnosis in mind.

Flare‐up reactions in severe drug hypersensitivity: infection or ongoing T‐cell hyperresponsiveness