Open AccessTP53 and PTEN as driver mutations in Zenker's carcinoma—a clinical presentation
Author(s) -
Noel Zsanett,
Hoeller Sylvia,
Bihl Michel,
Muller Laurent
Publication year - 2020
Publication title -
clinical case reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.21
H-Index - 9
ISSN - 2050-0904
DOI - 10.1002/ccr3.3169
Subject(s) - medicine , pten , presentation (obstetrics) , disease , oncology , bioinformatics , pathology , genetics , surgery , biology , pi3k/akt/mtor pathway , apoptosis
Zenker carcinoma is still being treated empirically because of the lack of evidence‐ based guidelines. We report for the first time about the genetic examination of this rare entity. The revealed mutations show genetic similarities with HPV(‐)HNSCC which suggests that well‐known therapeutic strategies may be applicable for this disease