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Key Clinical Message  Prolonged clotting times were observed in a patient with spontaneous hemorrhage. Analysis showed severe factor X deficiency due to clearance by a noninhibitory antibody. Lymphadenopathy identified on imaging led to diagnosis of marginal B‐cell lymphoma. Treatment of lymphoma with rituximab and chlorambucil resulted in complete disappearance of the bleeding disorder.

Successful treatment of a noninhibitory antibody‐mediated acquired factor X deficiency in a patient with marginal‐zone lymphoma