Open AccessSuccessful treatment of a noninhibitory antibody‐mediated acquired factor X deficiency in a patient with marginal‐zone lymphoma
Author(s) -
Meenhuis Annemarie,
Vliet Rianne,
Hudig Francisca,
Ypma Paula F.,
Schipperus Martin R.,
Hollestelle Martine J.
Publication year - 2015
Publication title -
clinical case reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.21
H-Index - 9
ISSN - 2050-0904
DOI - 10.1002/ccr3.294
Subject(s) - medicine , clotting factor , rituximab , lymphoma , marginal zone b cell lymphoma , chlorambucil , antibody , marginal zone , immunology , gastroenterology , chemotherapy , b cell , cyclophosphamide
Key Clinical Message Prolonged clotting times were observed in a patient with spontaneous hemorrhage. Analysis showed severe factor X deficiency due to clearance by a noninhibitory antibody. Lymphadenopathy identified on imaging led to diagnosis of marginal B‐cell lymphoma. Treatment of lymphoma with rituximab and chlorambucil resulted in complete disappearance of the bleeding disorder.