Open AccessImmunogenicity of pneumococcal vaccination in a patient with sickle hemoglobinopathy: a case report
Author(s) -
Clay E. Leila Jerome,
Burrell Tierra,
Belhorn Thomas,
ReddingLallinger Rupa
Publication year - 2015
Publication title -
clinical case reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.21
H-Index - 9
ISSN - 2050-0904
DOI - 10.1002/ccr3.276
Subject(s) - medicine , asplenia , meningitis , hemoglobinopathy , pneumococcal vaccine , splenectomy , vaccination , pediatrics , immunogenicity , pneumonia , pneumococcal disease , pneumococcal infections , streptococcus pneumoniae , thalassemia , immunization , pneumococcal vaccination , sepsis , immunology , population , hemolytic anemia , antibody , antibiotics , spleen , microbiology and biotechnology , biology , environmental health
Key Clinical Message Despite decrease in morbidity and mortality from invasive pneumococcal disease ( IPD ), individuals with asplenia remain at risk for IPD compared to the general population. This report describes a young adult with hemoglobin SD and documented splenic autoinfarction with pneumococcal sepsis, meningitis, and pneumonia within seven months of immunization with PPSV ‐23.